ABSTRACT
Nowadays, the topic of confrontation of personality is negative environmental factors are highly relevant. Violent social, economic changes in society postpone the imprint on the mental health of a person, especially girls, which directly affects the physical condition, causing stress, neurosis, depressive states, apathy, inadequate behaviour. Methods: This article gives concept of athlete girls’ involved in handball (n=184) psycho-emotional state and its influence on health and activities. Describes review of methods assessing the psycho-emotional state of a person. Analysed methods, used in the laboratory of Tashkent Institute Postgraduate Medical Education. The article focuses on the use of scale personal anxiety Spilberger-Khanin and Lusher. Results: light anxiety-depressive disorders in 45.0%, moderate violations were detected in 40% and severe in 15%. When testing for age characteristics, 70% of girls were over 17 years old. 30% of cases accounted for age gradation up to 17 years, which is the most prosperous age. the most severe type of personality disorders occurred among girls engaged in trainings during one year, because the girls prepared for the competition, they were more neurotic. The most acceptable period of time according to our research is 2 years. Disorders of moderate severity is detected in athletes during sports for 3 years. Conclusions: A change in the psycho-emotional state is indeed in close relationship with the physical state of a person. Experimental psychological testing of girls after increased loads revealed mild anxiety and depressive disorders in 45%, moderate 40% and severe 15%.
ABSTRACT
Type 2 diabetes mellitus [T2D] is a chronic metabolic disease regarded as insulin resistance and progressive failure of ? cells. Beta cells secretagogues are useful to reach satisfactory glycemic control. Glimepiride is a secondgeneration sulfonylurea excites pancreatic beta cells to discharge insulin. Glimepiride may be safer to use in patients with cardiovascular disease due to lack of destructive effects on ischemic preconditioning. It is effective in dropping fasting plasma glucose [FPG], postprandial glucose and glycated hemoglobin levels and is a useful and cost-effective option treatment for the management of T2D. Total 40 patients were selected from OPD setting at RSNPMTS Endocrinology center Ministry of Health Republic of Uzbekistan, and corresponding to criteria for inclusion / exclusion. 10 patients with T2D switched from receiving other forms of Glimepiride [Amaryl] on an identical dose of GlucoNovax in combination with biguanides [Metformin] denoted as group 1. At the same time the dose of biguanides [Metformin] was not altered for the period of the study. 10 patients with T2D switched from receiving other forms of Glimepiride [Amaryl] on an identical dose of GlucoNovax denoted as group 2.10 patients with T2D switched to the drug GlucoNovax from the drug Glibenclamide denoted as group 3. The control group received monotherapy with Amaryl it consist of 10 patients with T2D denoted as group 4. The severity of diabetic complaints in patients receiving the combination drug GlucoNovax with metformin significantly decreased by the end of the observation period and had an inclination to reduction in the 2nd and 3[rd] groups, along with the control group. 30 patients, receiving the drug Gluco Novax, 7 achieved blood glucose level parameters that corresponding to the high effectiveness of the drug [4 of them from 1[st] group [GlucoNovax+ Metformin], 1 in the 2[nd] group, 2 in the 3[rd] group]. 6 patients achieved blood glucose levels parameters, meeting the criteria of moderate effectiveness of the drug [4 of them from 1[st] group, 1 patient in the 2[nd] and 1 patient in the 3[rd] groups]. The given result may be, associated with initially high levels of compensation of carbohydrate metabolism, as well as a more effective influence on combination treatment with Metformin. The drug GlucoNovax appears to be an effective hypoglycemic agent in the treatment of T2D with good tolerability